Frank Emmert-Streib's Homepage



In theory, there is no difference between theory and practice. But, in practice, there is.

-- Jan L.A. van de Snepscheut




Currently, I am a Senior Fellow in the Department of Biostatistics and the Department of Genome Sciences at the University of Washington in Seattle (USA) in the group of John Storey. Before joining this group I was a Postdoctoral Research Associate in the Department of Bioinformatics with Arcady Mushegian at the Stowers Institute for Medical Research in Kansas City (USA). I studied Physics and Mathematics and obtained my Ph.D. in Theoretical Physics from the University of Bremen (Germany) and my Diploma (with distinction) as well as my Bachelor in Theoretical Physics from the University of Siegen (Germany).


Selected Publications
  1. F. Emmert-Streib and M. Dehmer
    Analysis of Microarray Data: A Network-Based Approach
    Wiley-VCH (2008).
  2. F. Emmert-Streib
    The Chronic Fatigue Syndrome: A Comparative Pathway Analysis
    Journal of Computational Biology, 14(7) (2007) 961-972.
  3. F. Emmert-Streib and A. Mushegian
    A Topological Algorithm for Identification of Structural Domains of Proteins
    BMC Bioinformatics, (2007) 8-237.
  4. F. Emmert-Streib and M. Dehmer
    Information Theoretic Measures of UHG Graphs with Low Computational Complexity
    Applied Mathematics and Computation, 190(2) (2007) 1783-1794.
  5. F. Emmert-Streib and M. Dehmer
    Topolocial Mappings between Graphs, Trees and Generalized Trees
    Applied Mathematics and Computation, 186(2) (2007) 1326-1333.
  6. F. Emmert-Streib
    Algorithmic Computation of Knot Polynomials of Secondary Structure Elemtents of Proteins
    Journal of Computational Biology, 13(8) (2006) 1503-1512.
  7. M. Dehmer, F. Emmert-Streib and J. Kilian
    A Similarity Measure for Graphs with low Computational Complexity
    Applied Mathematics and Computation 182(1) (2006) 447-459.
  8. F. Emmert-Streib
    A Heterosynaptic Learning Rule for Neural Networks
    International Journal of Modern Physics C 17(10) (2006) 1501-1520.
    preprint


I have always been fascinated in mathematics. Not only because one can use mathematics to create models, which describe nature, but also because it is of interest itself. My major interest is devoted to the design, development and application of mathematical methods in statistical data analysis, modeling and simulation. Because I am above all interested in phenomena from molecular biology statistical and computational methods from statistics, machine learning or information theory are playing a dominating role. It is important for me that my approach is data-driven to stay in close contact with the phenomenon. For this reason high-throughput data allowing to monitor the processes taking place on a systems level within a cell are of central importance for my research. In this context, especially network-based methods have been proven to be useful describing biological problems on the systems level.




Research interests

  • Computational Biology
  • Biostatistics
  • Information Theory and Statistical Learning
  • Computational Finance
  • Machine Learning

Further interests



News

  • ITSL 2008 Information Theory and Statistical Learning
    July 14-15, 2008, Las Vegas, Nevada (USA).
    Co-Chair of ITSL 2008.
  • ICSB 2007 The 8th International Conference on Systems Biology 2007
    October 1-6, 2007, Long Beach, California (USA).
    Scientific Review committee of ICSB 2007.
  • IEEE BIBE 2007 IEEE 7th International Symposium on Bioinformatics and Bioengineering
    October 14-17, 2007, Harvard Medical School, Massachusetts (USA).
    Session Chair of IEEE BIBE 2007.
  • MLMTA'07 - The 2007 International Conference on Machine Learning: Models, Technologies & Applications
    Submission deadline: March 20, 2007.
    June 25-28, 2007, Las Vegas, Nevada (USA).
    Co-Chair of MLMTA'07.
  • Workshop on Gene Networks: Theory and Application
    (in conjunction with BIOCOMP'06)
    Extended submission deadline: March 06, 2006.
    Organizer of the workshop.
  • CAMDA'06 (Critical Assessment of Microarray Data Analysis)
    Submission deadline: February 10, 2006
    Different data sets are provided including clinical, microarray, proteomics and SNP data concerning the Chronic Fatigue Syndrome (CFS). Find some useful information about the different data sets on Earl Glynn's homepage.

    CAMDA'06

    (If you have really sharp eyes you might see something. Thanks Earl :-))



Publications
(Sorted lists of my publications can be found here.)

Thesis

  1. F. Emmert-Streib
    Aktive Computation in offenen Systemen.
    Lerndynamiken in biologischen Systemen: Vom Netzwerk zum Organisms
    Ph.D. Thesis - Theoretical Physics
    Universität Bremen (Germany) (2003).
  2. F. Emmert-Streib
    Quantenmechanik eines nicht abgeschlossenen Zwei-Niveau-Systems
    Diploma Thesis - Theoretical Physics
    Universität Siegen (Germany) (1998).

Books

  1. F. Emmert-Streib
    Aktive Computation in offenen Systemen.
    Lerndynamiken in biologischen Systemen: Vom Netzwerk zum Organismus

    ISBN: 3-89820-790-0
    Mensch & Buch Verlag, Berlin (2004).
Proceedings (Editor)
  1. H. R. Arabnia, M. Dehmer, F. Emmert-Streib, M. Q. Yang: Proceedings of the 2007 International Conference on Machine Learning: Models, Technologies and Applications (MLMTA'07), CSREA Press (2006).
Proceedings (Associate Editor)
  1. H. R. Arabnia, H. Valafar: Proceedings of the 2006 International Conference on Bioinformatics & Computational Biology (BIOCOMP'06), F. Emmert-Streib (Associate Editor), CSREA Press (2006).
Articles

  1. F. Emmert-Streib and J.D. Storey
    Revealing Complex Diseases by Detecting Dynamical Disorder
    In preparation (2007).
  2. F. Emmert-Streib, L. Chen and J.D. Storey
    Statistical Analysis of the Transcriptional Regulatory Network of Saccharomyces cerevisiae
    In preparation (2007).
  3. F. Emmert-Streib and A. Mushegian
    Topological Classification of Protein Structures by Knot Polynomials
    In preparation (2007).
  4. L. Chen, F. Emmert-Streib and J.D. Storey
    Harnessing naturally randomized transcription to infer regulatory relationships among genes
    Submitted (2007).
  5. F. Emmert-Streib
    The Chronic Fatigue Syndrome: A Comparative Pathway Analysis
    Journal of Computational Biology, 14(7) (2007) 961-972.
  6. M. Dehmer, F. Emmert-Streib and T. Gesell
    A Comparative Analysis of Multidimensional Features of Objects Resembling Sets of Graphs
    Applied Mathematics and Computation, accepted (2007).
  7. F. Emmert-Streib and M. Dehmer
    Nonlinear Time Series Prediction based on a Power-Law Noise Model
    International Journal of Modern Physics C, accepted (2007).
  8. M. Dehmer and F. Emmert-Streib
    Structural Similarity of Directed Universal Hierarchical Graphs: A low Computational Complexity Approach
    Applied Mathematics and Computation, accepted (2007).
  9. F. Emmert-Streib and A. Mushegian
    A Topological Algorithm for Identification of Structural Domains of Proteins
    BMC Bioinformatics, (2007) 8-237.
  10. F. Emmert-Streib and M. Dehmer
    Information Theoretic Measures of UHG Graphs with Low Computational Complexity
    Applied Mathematics and Computation, 190(2) (2007) 1783-1794.
  11. M. Dehmer and F. Emmert-Streib
    Comparing large graphs efficiently by margins of feature vectors
    Applied Mathematics and Computation, 188(2) (2007) 1699-1710.
  12. F. Emmert-Streib, E. F. Glynn, C. Seidel, C. L. Bausch and A. Mushegian
    Detecting Pathological Pathways of the Chronic Fatigue Syndrome by the Comparison of Networks
    Critical Assessment of Microarray Data Analysis (CAMDA) (2006), accepted (to appear in 2007).
  13. F. Emmert-Streib and M. Dehmer
    Topolocial Mappings between Graphs, Trees and Generalized Trees
    Applied Mathematics and Computation, 186(2) (2007) 1326-1333.
  14. F. Emmert-Streib
    Algorithmic Computation of Knot Polynomials of Secondary Structure Elemtents of Proteins
    Journal of Computational Biology, 13(8) (2006) 1503-1512.
  15. F. Emmert-Streib
    A Heterosynaptic Learning Rule for Neural Networks
    International Journal of Modern Physics C 17(10) (2006) 1501-1520.
    preprint
  16. F. Emmert-Streib, M. Dehmer and C. Seidel
    Influence of Prior Information on the Reconstruction of the Yeast Cell Cycle from Microarray Data
    BIOCOMP'06 - The 2006 International Conference on Bioinformatics and Computational Biology, Arabnia, H.A. and Valafar, H. (Eds.) (2006) 477-482.
  17. F. Emmert-Streib and M. Dehmer
    Theoretical Bounds for the Number of inferable Edges in sparse Random Networks
    BIOCOMP'06 - The 2006 International Conference on Bioinformatics and Computational Biology, Arabnia, H.A. and Valafar, H. (Eds.) (2006) 472-476.
  18. M. Dehmer ,F. Emmert-Streib and O. Wolkenhauer
    Perspectives of Graph Mining Techniques
    Rostocker Informatik Berichte 30(2) (2006) 47-56.
  19. M. Dehmer, F. Emmert-Streib and J. Kilian
    A Similarity Measure for Graphs with low Computational Complexity
    Applied Mathematics and Computation 182(1) (2006) 447-459.
  20. F. Emmert-Streib
    Influence of the neural network topology on the learning dynamics
    Neurocomputing 69(10-12), 1179-1182 (2006).
  21. F. Emmert-Streib
    A Novel Stochastic Learning Rule for Neural Networks
    Advances in Neural Networks - Third International Symposium on Neural Networks, Lecture Notes in Computer Science (LNCS), 414-423 (2006).
  22. M. Dehmer, F. Emmert-Streib, A. Mehler and J. Kilian
    Measuring the Structural Similarity of Web-based Documents: A novel Approach
    International Journal of Computational Intelligence 3:1 (2006) 1-7.
  23. F. Emmert-Streib, M. Dehmer, J. Liu and M. Mühlhäuser
    Ranking Genes from DNA Microarray Data of cervical cancer by a local Tree Comparison
    International Journal of Biomedical Sciences 1:1 (2006) 17--22.
  24. F. Emmert-Streib and M. Dehmer
    First Studies of the Influence of Single Gene Perturbations on the Inference of Genetic Networks
    VIII. International Conference on Enformatika, Systems Sciences and Engineering, Krakow, Poland, International Academy of Sciences: Enformatika 10 (2005) 65--69.
  25. F. Emmert-Streib, M. Dehmer, G. H. Bakir and M. Mühlhäuser
    Influence of Noise on the Inference of Dynamic Bayesian Networks from Short Time Series
    VIII. International Conference on Enformatika, Systems Sciences and Engineering, Krakow, Poland, International Academy of Sciences: Enformatika 10 (2005), 70--74.
  26. M. Dehmer, F. Emmert-Streib, J. Kilian and A. Zulauf
    Towards Clustering of Web-based Document Structures
    VIII. International Conference on Enformatika, Systems Sciences and Engineering, Krakow, Poland, International Academy of Sciences: Enformatika 10 (2005), 304--309.
  27. F. Emmert-Streib
    Protein graph partitioning by mutually maximization of cycle distributions
    VI. International Conference on Enformatika, Systems Sciences and Engineering, Budapest, Hungary, International Academy of Sciences: Enformatika 8 (2005) 88-92.
  28. F. Emmert-Streib, M. Dehmer, J. Liu and M. Mühlhäuser
    A systems approach to gene ranking from DNA Microarray Data of cervical cancer
    VI. International Conference on Enformatika, Systems Sciences and Engineering, Budapest, Hungary, International Academy of Sciences: Enformatika 8 (2005) 82-87.
  29. M. Dehmer, F. Emmert-Streib, J. Kilian and M. Mühlhäuser
    Application of a similarity measure for graphs to web-based document structures
    VI. International Conference on Enformatika, Systems Sciences and Engineering, Budapest, Hungary, International Academy of Sciences: Enformatika 8 (2005) 77-81.
  30. F. Emmert-Streib and M. Dehmer
    A Systems Biology approach for the classification of DNA Microarray Data
    (2005), accepted.
  31. F. Emmert-Streib
    Stochastic Sznajd model in open community
    International Journal of Modern Physics C, 16(11) (2005) 1693--1700.
  32. F. Emmert-Streib, M. Dehmer and J. Kilian
    Classification of large graphs by a local tree decomposition
    Proceedings of the 2005 International Conference on Data Mining (DMIN'05), Editors: H.R. Arabnia, A. Scime (2005) 200--207.
  33. F. Emmert-Streib
    Active Learning in Recurrent Neural Networks Facilitated by a Hebb-like Learning Rule with Memory.
    Neural Information Processing - Letters and Reviews 9(2) (2005) 31--40.
  34. F. Emmert-Streib
    A neurobiologically motivated model for self-organized learning
    MICAI 2005: Advances in Artificial Intelligence, Lecture Notes in Computes Science (LNCS), Lecture Notes in Artificial Intelligence, Vol. 3789 Alexander Gelbukh and Hugo Terashima (Eds.) (2005) 415--424.
  35. F. Emmert-Streib
    Self-Reinforcement Learning: A neurobiologically motivated Model
    Annual Conference on Artificial & Computational Intelligence for Decision, Control and Automation in Engineering and Industrial Applications - International Conference on Machine Intelligence (ACIDCA-ICMI) (2005) 335--342.
  36. F. Emmert-Streib
    Self-organized annealing in laterally inhibited neural networks shows power law decay
    Neural Information Processing - Letters and Reviews, 7(3) (2005) 29-38.
  37. F. Emmert-Streib
    A novel stochastic Hebb-like learning rule for neural networks
    cond-mat/0307666 (2003).
  38. J. R. Otterpohl, F. Emmert-Streib and K. Pawelzik
    A constrained HMM-based approach to the estimation of perceptual switching dynamics in Pigeons
    Neurocomputing 38-40, 1495-1501 (2001).
  39. J. R. Otterpohl, J. D. Haynes, F. Emmert-Streib, G. Vetter and K. Pawelzik
    Extracting the Dynamics of Perceptual Switching from Noisy Behaviour: An Application of Hidden Markov Modeling to Pecking Data from Pigeons
    Journal of Physiology (Paris) 94 No 5-6 555-567 (2000).
  40. J.M. Herrmann, F. Emmert-Streib and K. Pawelzik
    Autonomous robots and neuroethology: Emergence of behavior from a sense of curiosity.
    In U. Rückert A. Löffler, F. Mondada, editor, Experiments with the Mini-Robot Khepera, Proceedings of the 1st Int. Khepera Workshop, pages 89-98, Paderborn. HNI-Verlagsschriftenreihe, Bd. 64. (1999).

Conferences
  1. F. Emmert-Streib, L. Chen and J.D. Storey
    Annotating Genes with unknown Function by a Systems Approach
    The 8th International Conference on Systems Biology (ICSB 2007), Long Beach, California, USA (2007).
  2. M. Dehmer and F. Emmert-Streib
    Structural Analysis of Graphs by using Information theoretic Functionals
    Colourings, Independence and Domination (CID), 12th Workshop on Graph Theory, Karpacz, Poland (2007).
  3. F. Emmert-Streib, L. Chen and J.D. Storey
    FDR Controlled Topological Core of the Transcriptional Regulatory Network of Saccharomyces cerevisiae
    Research in Computational Molecular Biology (RECOMB), California, USA (2007).
  4. F. Emmert-Streib and D. Zhu
    Inferring gene networks from microarray data by closed-loop optimization
    DIMACS Workshop on Dialogue on Reverse Engineering Assessment and Methods (DREAM), New York, USA (2006).
  5. E. F. Glynn, F. Emmert-Streib and A. Mushegian
    An Attempt to Categorize the Servity of the Chronic Fatigue Syndrome Disease using Affective Disorder Pathways
    Critical Assessment of Microarray Data Analysis (CAMDA) (2006).
  6. F. Emmert-Streib, M. Dehmer, J. Liu, J. Kilian and M. Mühlhäuser
    Gene ranking based on generalized tree alignment from DNA Microarray Data
    German Conference on Bioinformatics (GCB'05), University of Hamburg, Center for Bioinformatics, Germany (2005).
  7. F. Emmert-Streib and A. Mushegian
    A graph theoretical approach for the Identification of Protein Domains
    Intelligent Systems for Molecular Biology (ISMB), University of Michigan, Detroit, Michigan, USA (2005).
  8. M. Dehmer, F. Emmert-Streib and J. Kilian
    Applications of graph similiarity measures for generalized trees
    40th Czech and Slovak Conference on Graph Theory and Combinatorics (GRAPHS 2005), Budmerice, Slovakia (2005).
  9. F. Emmert-Streib and A. Mushegian
    Identification of protein domains
    LSRD, Life Sciences Institute, Kansas City , Missouri, USA (2005).
  10. F. Emmert-Streib and A. Mushegian
    Identifying the domains of a protein by a graph theoretical approach
    Pacific Symposium on Biocomputing (PSB), Hawaii, USA (2005).
  11. F. Emmert-Streib
    A stochastic Hebb-like learning rule for neural networks
    Verhandlungen der Deutschen Physikalischen Gesellschaft (DPG) DY 46.57
    Statistical Physics in biological Systems, Dresden, Germany (2003).
  12. F. Emmert-Streib and R. D. Henkel
    Hebb-like learning rule based on the principle of extremal optimization
    Dynamic Days Europe , Heidelberg, Germany (2002).
  13. F. Emmert-Streib, R. D. Henkel, K. Pawelzik
    Active Computation: On-line learning in the action-perception-cycle
    Concepts for Complex Adaptive Systems, HWK, Germany (2002).
  14. F. Emmert-Streib, R. D. Henkel and K. Pawelzik
    Aktive Computation in offenen Systemen
    Verhandlungen der Deutschen Physikalischen Gesellschaft (DPG) DY 42.3,
    Statistical Physics far from equilibrium I, Regensburg, Germany (2002).
  15. J. R. Otterpohl, F. Emmert-Streib and K. Pawelzik
    A constrained HMM-based approach to the estimation of perceptual switching dynamics in Pigeons
    Computational Neuroscience (CNS), Brugge, Belgium (2000).
  16. J. R. Otterpohl, J. D. Haynes, F. Emmert-Streib, G. Vetter and K. Pawelzik
    A Stochastic Model for the Estimation of Perceptual Switching Events in Pigeons
    FENS, Brighton, UK (2000).
  17. J. R. Otterpohl, J. D. Haynes, F. Emmert-Streib, G. Vetter and K. Pawelzik
    Extracting the Dynamics of Perceptual Switching from Noisy Behaviour: An Application of Hidden Markov Modeling to Pecking Data from Pigeons
    Aspects of Neural Dynamics, HWK , Germany (2000).

Unpublished
  • F. Emmert-Streib, G. H. Bakir
    Perception (2001).


Professional Affiliations
  • IEEE Information Theory Society
  • American Statistical Association (ASA)
  • International Society for Computational Biology (ISCB)
  • European Physical Society (EPS)
  • German Physical Society (DPG)



Dr. Frank Emmert-Streib
 
Institute: General Contact:
University of Washington 

Storey Lab 
Department of Biostatistics 
Department of Genome Sciences 
Phone: +001-206-685-0265
Fax: +001-816-926-4668
E-Mail
 
Postal Adress: CAS
1705 NE Pacific St, Box 357730 
Seattle, WA 98195-5065 
USA


  Counter: Free Hit Counters

Web-Administration - last modified 06/02/2007